Work

Anti-Androgenic Effect of Soybean Tempeh Extract in the Treatment of Polycystic Ovary Syndrome

Year: 2025

Type: article

Abstract: study, daidzein and genistein were docked to the androgen receptor (AR) and 17β-hydroxysteroid dehydrogenase (17β-HSD). Treatment with tempeh extract at 250 mg/kg body weight more effectively restored abnormal estrous cycles than metformin. Weight gain and testosterone levels also decreased in this group. Daidzein and genistein bound to AR inhibitor amino acids; however, only genistein showed high binding energy to 17β-HSD inhibitor amino acids. As an anti-androgen, the findings suggest that tempeh extract at 250 mg/kg body weight may serve as a dietary supplement for managing PCOS, potentially via AR inhibition.

Source: Preventive Nutrition and Food Science

DOI: 10.3746/pnf.2025.30.3.263

Authors: Cut Raihanah, Yenni Karlina, Saleh Wikarsa, Neng Fisheri Kurniati, Sukrasno Sukrasno

Institutions: Bandung Institute of Technology, Universitas Jenderal Achmad Yani

Language: English

Topic: Ovarian function and disorders

Subfield: Reproductive Medicine

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: hybrid

Funder: Institut Teknologi Bandung