Work

Evaluation of Calprotectin and Other İnflammatory Parameters in Patients with Schizophrenia

Year: 2025

Type: article

Abstract: Objective Schizophrenia is a long-term, serious mental health condition that affects thinking, emotions, and behavioral patterns. This study is the first study to investigate calprotectin levels and novel inflammatory indices such as NLR, PLR, SII, SIRI, and PIV in patients with schizophrenia. Methods This prospective case–control study involved 33 individuals diagnosed in patients with schizophrenia and 50 healthy participants. The research was conducted in accordance with the Helsinki Declaration, with informed consent obtained from all subjects. The blood parameters assessed included neutrophil, lymphocyte, platelet, and monocyte levels. Calprotectin concentrations were analyzed using an enzyme-linked immunosorbent assay (ELISA). Results Inflammatory indices, including SII, SIRI, NLR, and PLR, varied significantly between the study groups (p < 0.001). However, no significant differences were observed in monocyte, platelet, and PIV levels (p > 0.05). Calprotectin levels also showed a statistically significant difference between the groups (p < 0.001). The area under curve (AUC) of the calprotectin score for schizoprenia was 0.963. Conclusion These results suggest that SII, SIRI, NLR and calprotectin could serve as reliable biomarkers for monitoring treatment response, and potentially predicting clinical outcomes in patients with schizophrenia.

Source: Bratislavské lekárske listy/Bratislava medical journal

DOI: 10.1007/s44411-025-00235-0

Authors: Huseyin Erdal, Medine Giynas Ayhan, Ikbal Inanli

Institutions: Aksaray University, Sağlık Bilimleri Üniversitesi, SBÜ Beyhekim Training and Research Hospital

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,590