Work

N -Acetylcysteine and pro-adrenomedullin dual-crosslinked gelatin–chitosan hydrogels with enhanced mechanical and mineralization performance

Year: 2025

Type: article

Abstract: < 0.01). These findings suggest that NAC not only reinforces the mechanical strength of hydrogel scaffolds designed for temporary support in non-load-bearing bone defects, but also acts as a bioactive agent upon release. Its combination with the pro-adrenomedullin peptide (PAMP) results in synergistic effects on mineralization. GCNP hydrogels are therefore promising candidates for drug delivery and bone tissue regeneration.

Source: RSC Advances

DOI: 10.1039/d5ra03349g

Authors: Tonatzin Zertuche-Arias, Manuel Alatorre-Meda, Ignacio A. Rivero, Patricia Juárez, Ana B. Castro-Ceseña

Institutions: Centro de Investigación Científica y de Educación Superior de Ensenada, Universidad Nacional Autónoma de México, Tecnológico Nacional de México, Instituto Tecnológico de Tijuana

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,042