Work

Gaps in the Parkinson's disease therapeutic clinical pipeline: A focus on approaches targeting disease pathobiology

Year: 2025

Type: review

Abstract: The understanding of the pathobiology of Parkinson's disease (PD) is evolving, based largely on genetic discoveries. Despite a rich pipeline of potential therapies addressing aspects of the underlying biology of the disease, there is currently no available disease-modifying therapy for PD. In this short commentary, we review the status of the relevant pipeline and highlight areas where alternative or complementary approaches could also be advanced to the stage of clinical trials, with the ultimate goal of providing meaningful clinical benefit to patients and their families. The further evolution of biomarkers, cellular and animal models of the disease and delivery methods will be crucial to this end.

Source: Journal of Parkinson s Disease

DOI: 10.1177/1877718x251354935

Authors: Christos Koros, Brian Fiske, Leonidas Stefanis

Institutions: National and Kapodistrian University of Athens, Eginition Hospital, Michael J. Fox Foundation, Biomedical Research Foundation of the Academy of Athens

Language: English

Topic: Parkinson's Disease Mechanisms and Treatments

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4411880870

FWCI: 0.493

Cites: 121

Cited by: 3

Related to: 10