Work

In Vitro Comparison of the Efficacy of Different Soft Tissue Grafting Materials in Promoting Fibroblast Proliferation

Year: 2025

Type: article

Abstract: Objective: This study evaluated the ability of Fibro-Gide® and Mucoderm® collagen matrices to stimulate fibroblast proliferation. Materials and Methods: The study tested two collagen matrices, Mucoderm® and Fibro-Gide®, on human gingival fibroblasts. Surface roughness, cell viability, and collagen quantities were measured using profilometers and ELISA. Results: Fibro-Gide® outperformed Mucoderm® in terms of surface roughness (2.75 μm) and cell survival, while ELISA findings showed a greater collagen type and a higher optical density (0.920 OD). Conclusion: Fibro-Gide® showed better fibroblast proliferation and extracellular matrix production, indicating promise for tissue regeneration and remodeling in periodontal and peri-implant applications, while Mucoderm® remains viable.

Source: Journal of Pharmacy And Bioallied Sciences

DOI: 10.4103/jpbs.jpbs_740_25

Authors: Rajendran Senthilnathan, Neelam Das, Atika Ismail, Rupali Ravindra Borade, Anitha Subbappa, Lakshmi S. Anand

Institutions: Sree Balaji Dental College and Hospital, Kothiwal Dental College and Research Centre, JSS Academy of Higher Education and Research, JSS Dental College and Hospital

Language: English

Topic: Periodontal Regeneration and Treatments

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $250