Year: 2025
Type: article
Abstract: Melanoma is an aggressive form of skin cancer known for its ability to avoid detection by the immune system and resist treatment. This study explores the role of PTPN6, a protein linked to lactate, as both an oncogene and an immune-related biomarker in melanoma. Using computational tools, we examined the expression and mutation patterns of lactate-related genes in skin cutaneous melanoma (SKCM) and identified different patient groups based on prognosis. Our results show that PTPN6 plays a key role in regulating immune responses, affecting the behavior of immune cells. This suggests that PTPN6 could be a promising target for new therapies. By combining insights from metabolism and immunology, our research lays the groundwork for personalized treatments that may improve outcomes for melanoma patients.
Source: Discover Oncology
Authors: Piaopiao Bian, Shaoyan Liu, Qiuping Luo, Zewen Feng, Sanyan Li, Wei Zhang
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,690
OpenAlex ID: W4411898974