Year: 2025
Type: article
Abstract: Mitochondria assemble in a dynamic tubular network. Their morphology is governed by mitochondrial fusion and fission, which regulate most mitochondrial functions including oxidative phosphorylation. Yet, the link between mitochondrial morphology and respiratgion remains unclear. Here, we uncover a mitochondrial morphology dedicated to respiratory growth of Saccharomyces cerevisiae, which we refer to as "Ringo". The Ringo morphology is characterized by stable constrictions of mitochondrial tubules. Ringo constrictions are mediated by the yeast dynamin Dnm1 and, unlike mitochondrial fission, occur in the absence of contacts with the endoplasmic reticulum. Our data show that blocking formation of the Ringo morphology correlates with decreased respiration, decreased expression of OXPHOS subunits and perturbed mitochondrial DNA distribution. These results open important perspectives about the link between mitochondrial form and function.
Source: Nature Communications
Institutions: Centre National de la Recherche Scientifique, Institut Pasteur, Université Paris Cité, Sorbonne Université, Institut de Biologie Physico-Chimique, Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes, Biologie cellulaire physiologique et pathologique, Max Planck Institute of Biophysics, Saarland University, University of Würzburg
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $6,990
Awards: G120131529, G1418548345, G1979782309, G2103271052, G2132841066, Paris Sciences et Lettres, G282427092, G3010527862, Genome instability induced in telomere-mediated replicative senescence and first steps of oncogenesis, G3325690611, G3489752117, G3953683450, G4190806336, G434337789, G450923295, G471331628, Structure, Assembly and Biophysical Properties of Mitofusins, G5188301940, Institut Convergences pour l’étude de l’Emergence des Pathologies au Travers des Individus et des populatiONs, G6048378198, G6759105742, G6803667113, G7240651115, Integrative Biology of Emerging Infectious Diseases, G782245399, The Paris DYNAMO Fellowship Programme, Impact of Cdk activity during meiotic divisions on the generation of healthy gametes, G8670608220, Dynamique des membranes transductrices d'énergie : biogénèse et organisation supramoléculaire., Structural dissection of mitochondrial tethering through super-resolution imaging, G937427620
OpenAlex ID: W4411900521