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Clinically probable paraneoplastic vasculitic peripheral neuropathy in primary central nervous system lymphoma: a case report

Year: 2025

Type: article

Abstract: Primary central nervous system lymphoma (PCNSL) is a malignant tumor known to cause direct mass effects and various paraneoplastic syndromes. However, paraneoplastic vasculitic peripheral neuropathy is rarely associated with PCNSL. In this case report, we describe a patient with PCNSL who presented with probable paraneoplastic vasculitic peripheral neuropathy. The patient initially experienced recurrent pain and weakness in bilateral lower limbs for two years, followed by a sudden decline in consciousness over two days. A biopsy of the right sural nerve revealed probable vasculitic peripheral neuropathy, and the diagnosis of PCNSL was confirmed through brain biopsy.

Source: BMC Neurology

DOI: 10.1186/s12883-025-04285-3

Authors: Zhuangzhuang Zhang, Chen Ling, Yingshuang Zhang, Weiping Sun, Zhaoxia Wang, Lingchao Meng

Institutions: Peking University First Hospital, Peking University Third Hospital

Language: English

Topic: Peripheral Neuropathies and Disorders

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090