Efficacy and safety of ultrasound-guided percutaneous aspiration-sclerotherapy with anhydrous ethanol for adult simple renal cyst: a multicenter, prospective, randomized controlled trial
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Background: Percutaneous aspiration-sclerotherapy (PAS) is one of the most common treatments for renal cysts. In this study, we conducted an unequal-group, superior, randomized controlled trial to evaluate the safety and efficacy of ultrasound-guided PAS with anhydrous ethanol involving single-session multiple injections for simple renal cysts (SRCs) in adults by comparing percutaneous aspiration therapy with or without sclerosis agents. Methods: We prospectively collected data from multiple healthcare organizations in China on 149 patients with SRCs from August 2017 to October 2018. The patients enrolled in the study underwent percutaneous aspiration therapy with (treatment group, n=120) or without (control group, n=29) anhydrous ethanol. Treatment success was defined as a reduction in renal cyst volume of 87.5% or more from pre-treatment volume after 24 weeks of treatment. All patients were followed up at weeks 12 and 24. The patient profiles, reduced volume of cysts, treatment success rates, recurrence rates, and complication rates of two groups were compared. Results: . 13.79%; P<0.001). Conclusions: PAS with anhydrous ethanol combined with single-session multiple injections is a safe and effective treatment for SRCs. Trial Registration: Chinese Clinical Trial Registry identifier: ChiCTR-TRC-10001114.
Authors: Shu Luo, Ping Feng, Yongzhong Li, Shuhua Shi, Lichuan Yang, Yanrong Yang, Rongchen Wang, Xuelian Chen, Jiaojiao Zhou
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4411901754