Continuous-time random walk and fractional order calculus models histogram analysis of glioma biomarkers, including IDH1, ATRX, MGMT, and TERT, on differentiation
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: The focus of neuro-oncology research has changed from histopathologic grading to molecular characteristics, and medical imaging routinely follows this change. This study aimed to demonstrate the feasibility of using continuous-time random walk (CTRW) and fractional order calculus (FROC) models, together with histogram analysis, in identifying the states of molecular biomarkers of diffuse gliomas in adults. Methods: test. The diagnostic performance of each diffusion parameter was evaluated using receiver operating characteristic (ROC) curve. Results: , respectively. Conclusions: The CTRW and FROC models demonstrate good diagnostic performance in predicting different molecular subtypes in diffuse gliomas, and provide new imaging biomarkers for probing tumor structural heterogeneity at a subvoxel level.
Authors: Yujie Ding, Hongquan Zhu, Yuanhao Li, Yufei Liu, Yan Xie, Jiaxuan Zhang, Yan Fu, Shihui Li, Li Li, Nanxi Shen, Wenzhen Zhu
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4411901755