Work

Anchoring cobalt nanoparticles on to the grafted mono(6-ethylene-diamino-6-deoxy)-β-cyclodextrin to magnetic chitosan for enhanced catalytic performance of the synthesis of pyrano[2,3-c]pyrazole-3-carboxylates

Year: 2025

Type: article

Abstract: A novel magnetic nanocatalyst based on nickel ferrite coated with chitosan and ethylenediamine-functionalized β-cyclodextrin and decorated with cobalt nanoparticles (NiFe 2 O 4 @Cs-CDEDA@Co) was developed for the efficient green synthesis of heterocycles. This bifunctional catalyst provided Lewis acidic and basic sites, enabling sequential Knoevenagel condensation, Knorr-type cyclization, and Michael addition. Under mild aqueous conditions (H₂O/EtOH, 50 °C), twenty-eight derivatives of dihydropyrano[2,3-c]pyrazole and pyranopyrazolopyrimidine were synthesized in excellent yields in a short time. The catalyst demonstrated excellent stability (confirmed by XRD), negligible metal leaching (ICP), and reusability over six cycles without performance loss. Structural characterization (FTIR, XRD, SEM, TEM, TGA, VSM, EDX) confirmed homogeneous morphology and nanoscale particle sizes (40–50 nm). These findings highlight the potential of this nanocatalyst platform for sustainable and scalable multicomponent reactions under environmentally benign conditions.

Source: Carbohydrate Polymer Technologies and Applications

DOI: 10.1016/j.carpta.2025.100923

Authors: Maryam Mousavi-Ebadi, Javad Safaei-Ghomi, Hossein Mojtabazadeh

Institution: University of Kashan

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $2,790

Funder: University of Kashan