Work

Cellulose-based electrochemical recognition of doxorubicin in human biofluid

Year: 2025

Type: article

Abstract: Doxorubicin (DOX) remains a crucial medication in cancer treatment, providing effective therapeutic options for a range of malignancies. As such, it necessitates meticulous monitoring and the development of reliable detection methods in biological samples to optimize dosage and avoid toxic concentrations. In this research, three-electrode micro-scale sensors were fabricated on paper using pen-on-paper technology. Highly conductive silver ink was synthesized, loaded into a ball-pen, and then used to draw electrodes onto a cellulose substrate. Results demonstrated that the ink dried instantaneously at room temperature upon deposition on the cellulose surface. Moreover, the developed three-electrode sensor exhibited excellent thermal stability, maintaining functionality at temperatures as high as 150°C. Mechanical bending of the sensor had no impact on its electrical characteristics, and moisture absorption did not alter either the electrical conductivity or resistance of the electrodes. Following this, the sensor’s electrochemical performance was assessed for detecting DOX in human plasma samples. The micro-scale sensor achieved a wide linear detection range between 10 and 1000 nM, with a low quantification limit of 10 nM. This study underscores the promise of nanoink-based cellulose sensors as sensitive, affordable, and scalable solutions for biomedical diagnostics.

Source: Carbohydrate Polymer Technologies and Applications

DOI: 10.1016/j.carpta.2025.100927

Authors: Rokhsareh Ebrahimi, Mohammad Hasanzadeh, Nasrin Shadjou

Institutions: Tabriz University of Medical Sciences, Urmia University

Language: English

Topic: Electrochemical sensors and biosensors

Subfield: Electrical and Electronic Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,790