Global Burden of Female Breast Cancer Attributable to High Fasting Plasma Glucose From 1990 to 2021 and Projections to 2046: An Analysis for the Global Burden of Disease Study 2021
Year: 2025
Type: article
Abstract: BACKGROUND: High fasting plasma glucose (HFPG) plays an important role in the progression of breast cancer. This study aims to assess the global time trends of female breast cancer attributable to HFPG from 1990 to 2021 and projections to 2046. METHODS: This study obtained the number and age-standardised rate of deaths and disability-adjusted life years (DALYs) of female breast cancer burden attributable to HFPG by age, region, country, and socio-demographic index (SDI) from 1990 to 2021. Average Annual Percentage Change (AAPC) was analysed to assess time trends in female breast cancer burden attributable to HFPG. The age-period-cohort model was used to project the global burden by 2046. RESULTS: In 2021, 4.62% of female breast cancer deaths (30,000) and 4.04% of DALYs (820,000) globally were attributed to HFPG. Compared with 1990, the age-standardised mortality rate (ASMR) and age-standardised DALY rate (ASDR) increased, with AAPCs of 0.76 (95% CI: 0.71, 0.89) and 0.86 (95% CI: 0.84, 0.98), respectively. The burden of breast cancer attributable to HFPG was higher in the elderly and low SDI regions. Additionally, the burden of female breast cancer attributable to HFPG is projected to continue to increase through 2046. CONCLUSIONS: The burden of female breast cancer attributable to HFPG has increased over the past three decades and will continue to increase over the next 25 years. Therefore, it is important to control blood sugar to reduce the burden of breast cancer.
DOI: 10.1002/dmrr.70063
Authors: Donglin Jiang, Siyao Ma, Yangxue Wu, Jicun Zhu, Qian Yang, Ling Liu, Tiandong Li, Yin Lu, Yuqi Liu, Peng Wang, Keyan Wang, Jianxiang Shi, Hua Ye
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4411906004