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Supplementary Figure S17 from Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation

Year: 2025

Type: supplementary-materials

Abstract: Supplementary Figure S17. Cell state classification in AML pt.90240 primary and xenograft samples A) Unsupervised UMAP embedding and AML cell type assignments of scRNA-seq from primary samples of AML pt.90240. B) Unsupervised UMAP embedding and AML cell type assignments from patient-derived xenograft (PDX) samples of AML pt.90240. C) Density plot of unsorted bulk, CD34+CD38- sorted, and CD34-CD38+ sorted primary fractions from AML pt.90240. D) Density plot of PDX generated from CD34+CD38- primary cells and PDX generated from CD34-CD38+ primary cells from AML pt.90240. E) BoneMarrowMap projection of primary AML fractions from (C). F) BoneMarrowMap projection of xenografted AML cells from (D).

DOI: 10.1158/2643-3230.29444485

Authors: Andy G.X. Zeng, Ilaria Iacobucci, Sayyam Shah, Amanda Mitchell, Gordon Wong, Suraj Bansal, David Chen, Qingsong Gao, Hyerin Kim, James A. Kennedy, Andrea Arruda, Mark D. Minden, Torsten Haferlach, Charles G. Mullighan, John E. Dick

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4411907313

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