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Supplementary Figure S9 from Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation

Year: 2025

Type: supplementary-materials

Abstract: Supplementary Figure S9. Representative samples from each AML differentiation pattern A) For each AML differentiation pattern defined from cell state composition analysis, projection results for each of two additional representative scRNA-seq samples are depicted. Patient ID and originating dataset are labeled accordingly. B) Aggregate profiles of each AML differentiation pattern. For each differentiation pattern, cells were sampled evenly across constituent patient samples until a total of 3,000 cells was obtained and plotted for each differentiation pattern.

DOI: 10.1158/2643-3230.29444452

Authors: Andy G.X. Zeng, Ilaria Iacobucci, Sayyam Shah, Amanda Mitchell, Gordon Wong, Suraj Bansal, David Chen, Qingsong Gao, Hyerin Kim, James A. Kennedy, Andrea Arruda, Mark D. Minden, Torsten Haferlach, Charles G. Mullighan, John E. Dick

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4411907428

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