Year: 2025
Type: article
Abstract: biochemical and structural experiments. The binding of itaconate could inhibit transamination activity of BCAT and regulate the metabolism of branched-chain amino acids (BCAAs) in lipopolysaccharide (LPS)-activated inflammatory macrophages. This study offers a valuable resource that helps decipher novel and comprehensive functions of ITA in macrophages during the immune response and other related biological processes.
Source: Chemical Science
DOI: 10.1039/d5sc02378e
Authors: Yunzhu Meng, Tiantian Wei, Chenlin Zhang, Anqi Yu, Yuan Liu, Junyu Xiao, Chu Wang
Institutions: Peking University, Beijing National Laboratory for Molecular Sciences, Center for Life Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering, Ministry of Education, State Key Laboratory of Protein and Plant Gene Research, State Key Laboratory of Natural and Biomimetic Drugs
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4411924909