PorelisTM, a standardized purple tea extract, improves adipocyte functionality by regulating the leptin and adiponectin levels in high-fat diet-induced C57BL/6 mice.
Year: 2025
Type: article
Abstract: Objectives: , 3-5% GHG) is demonstrated in high-fat-diet-induced mice. Materials and Methods: Male C57BL/6 mice (20±2 g) were divided into five groups (n=8). In a 12-week study, the control group was given a normal diet, and the other groups were given HFD (60 % kcal from fat) for 12 weeks. The treatment groups received Porelis at 25, 50, and 100 mg/kg body weight, PO. Results: = 223.3 µg/ml). Conclusion: Porelis exerts antiobesity activity in mice by regulating adipogenesis and energy homeostasis. Our data encourages further validation of Porelis-mediated weight loss effects in human subjects.
Source: PubMed
Authors: Heggar Venkataramana Sudeep, Kuppam Sundeep, Karempudi Venkatakrishna, Amrutha Raj, Ranganath Bhumika, Thammatadhahalli Parameshwarappa Prasanna Kumar, Kodimule Shyamprasad
Language: English
Topic: Tea Polyphenols and Effects
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4411927779