Work

MINFLUX: μs and nm precision 3D tracking of dynamic lipid mobility on nanoparticles

Year: 2025

Type: article

Abstract: MINFLUX microscopy opened unique opportunities to investigate complex molecular systems at a single molecule level with μs temporal and nm spatial resolutions in 3D. Here, we demonstrate its use for the characterization of nanomaterials, providing a framework for MINFLUX imaging and data analysis tailored to understanding the complex dynamics of nanosized Silica-Supported Lipid Bilayers (SSLBs).

Source: Nanoscale

DOI: 10.1039/d5nr00948k

Authors: Laurence W. Fitzpatrick, Laura Woythe, Ziqiang Huang, Sebastian Schnorrenberg, Timo Zimmermann, Lorenzo Albertazzi

Institutions: Eindhoven University of Technology, European Molecular Biology Laboratory

Language: English

Topic: Advanced Fluorescence Microscopy Techniques

Subfield: Biophysics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: Boehringer Ingelheim, European Molecular Biology Laboratory, Boehringer Ingelheim Stiftung, European Research Council

Award: G1150932353