Improving Solubility and Dissolution Characteristics of Dapoxetine Hydrochloride through the Liquisolid Compact Method
Year: 2025
Type: article
Abstract: This study aimed to enhance the solubility and dissolution properties of Dapoxetine hydrochloride (DXH) tablets by using of novel method i.e., liquisolid compact technology (LCT). A total of 9 formulations of DXH tablets were prepared by using carrier materials like microcrystalline cellulose and coating materials like lactose, silica, and starch. In out of nine formulations Super disintegrants like cross povidone (CP) in F1–F4 and Cross Carmellose Sodium in F5–F9 added. All formulations were evaluated for both pre compressional and post compressional evaluation parameters. Based on the evaluation parameters, the F6 formulation exhibited superior dissolution characteristics compared to others, indicating enhanced solubility rates. In vitro dissolution studies showed significantly improved release rates for DXH tablets.X-ray diffraction (XRD) analysis revealed a reduction in crystallinity, further supporting enhanced dissolution. Scanning electron microscopy (SEM) confirmed uniform dispersion of drug particles in the optimized formulation, leading to improved drug release. The absence of notable interactions between the drug and excipients was confirmed via FTIR analysis, ensuring formulation stability. In conclusion, LCT effectively enhanced the dissolution rate of DXH, demonstrating its potential as a promising approach for improving poorly water-soluble drugs.
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4411930617