aEEG Assessment for Short-Term Outcome Prognosis Prediction in Hypoxic Ischemic Encephalopathy: An 11-Year Experience
Year: 2025
Type: article
Study design: Observational Study
Abstract: in Hypoxic-Ischemic Encephalopathy: An 11-Year Experience H ypoxic-ischemic encephalopathy (HIE) is a condition of brain damage, characterized by reduced blood (ischemia) and oxygen (hypoxia) flow in the fetus or infant during or after birth.[1] Both preterm and term newborns are affected, and it is seen at the rate of 1-4/1000 live births in developed countries and 26/1000 in developing countries.HIE continues to be one of the most common causes of neurological disability and death in newborn infants (>1 million neonatal deaths per year worldwide).[1,2] According to the 2008 and 2023 data of the Turkish Neonatology Society Hypoxic-Ischemic Encephalopathy Working Group, HIE was determined in 2.6/1000, 2.13/1000 live births and in 1.2%, 1.55% of patient in Neonatal Intensive Care Units in Türkiye, respectively.[3,4] Objectives: Hypoxic-ischemic encephalopathy (HIE) continues to be a predominant cause of morbidity and mortality in neonates.Therapeutic hypothermia (TH) is the only method with proven neuroprotective effects, and the aim of this study was to evaluate the short-term results of patients treated with TH.Methods: Demographic, clinical characteristics, laboratory and aEEG results of patients who received TH treatment with a diagnosis of Stage II or Stage III HIE according to modified Sarnat staging in the Neonatal Intensive Care Unit were analyzed retrospectively.Results: A total of 101 patients were included in the study.The mean gestational age of the patients was 38.8±1.5 weeks, the mean birth weight was 3215±499.5g, and 40.6% were female.According to the modified Sarnat staging, 50.5% of the patients were evaluated as Stage II, and the others as Stage III HIE.The most common peripartum risk factors were meconium delivery (25.7%) and prolonged or difficult labor (20.7%).Mortality rates in patients with Stage II and Stage III HIE were 5.9% and 26%, respectively.In one of the patients who died, the 6th-hour aEEG background activity was moderately abnormal, and in 15 patients there was a severely abnormal voltage pattern.Acute kidney injury was found to be the most effective factor in mortality.Conclusion: In our study, it was concluded that the mortality rate of newborns diagnosed with Stage III HIE was higher, the biggest impact factor on mortality was acute kidney injury, and 6th-hour voltage activity in aEEG monitoring was useful in predicting prognosis.
Author: Muhittin Celik
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4411931020