SCN–IgG functionalized NaYF 4 :Yb 3+ /(Er 3+ ,Tm 3+ ) upconversion nanoparticles for targeted fluorescence imaging of liver cancer cells
Year: 2025
Type: article
Abstract: cores with uniform morphology and successful surface modification. The functionalized nanoparticles exhibited strong upconversion luminescence under 980 nm excitation, with multicolor emission dominated by red light (∼660 nm). Fluorescence microscopy and flow cytometry demonstrated selective labeling of HepG2 liver cancer cells, achieving a labeling efficiency of 18.10% for SCN-IgG-conjugated nanoparticles-significantly higher than in unmodified controls. These findings demonstrate that SCN-IgG-functionalized UCNPs are effective and selective nanoprobes for targeted fluorescence imaging and hold promise for the early diagnosis of liver cancer.
Source: RSC Advances
DOI: 10.1039/d5ra03912f
Authors: Ha Thi Phuong, Tran Thu Huong, Le Thi Vinh, Do Thi Thao, Le Anh Tu, Tong Quang Cong, Nguyen Duc Van, Tran Quoc Tien
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,042
Award: G5535543023
OpenAlex ID: W4411932746