Medial lethal concentration 50 (LC50) of a Chlorantraniliprole-based insecticide in Danio rerio
Year: 2025
Type: article
Abstract: Chlorantraniliprole (CAP) is a widely used insecticide whose potential toxicity to non-target aquatic organisms remains a concern. This study evaluates the acute toxicity, developmental toxicity of a chlorantraniliprole-based insecticide in zebrafish (Danio rerio), a standard model for toxicological research. One-hour post-fertilization embryos were exposed to varying concentrations (7.4–74 µg/ml) to determine the median lethal concentration (LC50). The LC50 was 17.56 µg/ml, with dose-dependent mortality observed. Initial mortality was low during the first 72 hours but increased sharply post-hatching, indicating time-dependent toxicity mediated by the protective chorion. These findings reveal CAP’s emphasizing the need for stringent environmental monitoring of this insecticide.
Authors: Mugdha M Desai, Vikas V Karande, BC Ghumare, CS Mote, SN Jadhav, MD Meshram, TC Shende
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4411939555