The Role of Dandelion (Taraxacum officinale) in Liver Health and Hepatoprotective Properties
Year: 2025
Type: review
Abstract: Background: Taraxacum officinale (T. officinale), commonly known as dandelion, is a plant with recognized therapeutic properties in both traditional and modern medicine. Historically, it has been used to treat various conditions, particularly liver disorders, owing to its antioxidant and anti-inflammatory activities. This narrative review focuses on its biological activity, with an emphasis on hepatoprotective effects. Methods: We performed a compilation and analysis of published studies on the effects of T. officinale in animal models and its potential application in liver diseases. Results: Preclinical studies have reported that extracts of this plant protect against liver damage induced by toxic agents such as alcohol, carbon tetrachloride, and paracetamol. Among the most relevant and predominant bioactive compounds of T. officinale is taraxasterol, which modulates inflammatory and oxidative stress pathways, helping to prevent liver damage. Conclusions: While preclinical studies are promising, further clinical trials are essential to confirm the safety and efficacy of T. officinale in the treatment of liver diseases. Determining the optimal dosing, evaluating its potential as an adjuvant in pharmacological treatments, as well as evaluating possible interactions with conventional drugs, is necessary for the potential use of T. officinale as an adjuvant agent in the treatment of liver diseases.
Source: Pharmaceuticals
DOI: 10.3390/ph18070990
Institutions: Universidad de Talca, Catholic University of the Maule
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,499
OpenAlex ID: W4411951668