Work

The Peptide Paradox in Pharmacology of Obesity

Year: 2025

Type: article

Abstract: Peptide biology is a fascinating subject, and peptidepharmacology even more so. Peptides have multiple bodilyfunctions, including their work as hormones and metabolicmodulators. However, certain pharmacodynamic andkinetic properties of peptides used in obesity result inparadoxical outcomes. It is helpful for the treating clinicianto be aware of these peptide paradoxes, which not onlyhelp in understanding the rationale of using these drugsbut also help to explain their differences in clinical actions. Keywords: biological paradox, dual agonists, GIP receptoragonists, GLP receptor agonists, glucagon agonists,peptide biology, semaglutide, tirzepatide, triple agonists,

Source: Journal of the Pakistan Medical Association

DOI: 10.47391/jpma.25-53

Authors: Sanjay Kalra, Amandeep Singh, Nitin Kapoor

Institutions: Chandigarh University, Bharti Hospital, All India Institute of Medical Sciences, Baker Heart and Diabetes Institute, Christian Medical College, Vellore

Language: English

Topic: Pharmacology and Obesity Treatment

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $650