Work

Relationship Between a Novel Model of Insulin Sensitivity and Arterial Stiffness in Non-Obese Patients with Type 2 Diabetes: A Cross-Sectional Study

Year: 2025

Type: article

Abstract: Aim: Insulin resistance (IR) is closely associated with arterial stiffness (AS) and cardiovascular diseases (CVDs). Recently, several non-insulin-based IR surrogate markers have been demonstrated to be related to AS. The natural log transformation of the glucose disposal rate (log e GDR) is a novel indicator of insulin sensitivity (IS) developed in patients with type 2 diabetes (T2D). We aim to investigate the relationship between the log e GDR and AS in non-obese patients with T2D. Methods: A cross-sectional study of 790 non-obese patients with T2D were included. Clinical and biochemical characteristics were collected. AS was assessed by brachial-ankle pulse wave velocity (baPWV), and according to the baPWV levels, patients were divided into two groups: AS group (baPWV ≥ 1800 cm/s) and non-AS group (baPWV < 1800 cm/s). The correlation between AS and log e GDR was analyzed. Results: Compared with the non-AS group, the log e GDR decreased in the AS group (P < 0.001). With the tertiles of log e GDR increased, the bapWV and the prevalence of AS were decreased (both P < 0.001). Univariate analysis showed that the log e GDR was negatively correlated with the baPWV and AS (both P < 0.001). Furthermore, multivariate regression analyses demonstrated that the log e GDR was independently associated with bapWV (β: − 0.162; P < 0.001) and AS (OR: 0.286; 95% CI: 0.110– 0.743). Integrating log e GDR modestly improved the ability of the model to identify AS (Net reclassification improvement (NRI): 0.043, 95% CI 0.009– 0.079, P = 0.011). Conclusion: The log e GDR is independently correlated with AS in non-obese patients with T2D, and its utility for risk stratification requires further validation. Keywords: type 2 diabetes, baPWV, insulin resistance, Log e GDR

Source: Diabetes Metabolic Syndrome and Obesity

DOI: 10.2147/dmso.s510884