Work

Figure 5 from Identification of the Distinct Immune Microenvironment Features Associated with Progression Following High-Dose Melphalan and Autologous Stem Cell Transplant in Multiple Myeloma

Year: 2025

Type: other

Abstract: Cell–cell interaction networks of disease progressors and nonprogressors after ASCT. A, Differential heatmap comparing the interaction weights between each cell type in progressors and nonprogressors. Rows correspond to different sender cells (ligands), and columns correspond to receivers (receptors). B, Bar plot showing signaling networks with larger (or fewer) differences based on their Euclidean distance between progressors and nonprogressors. C, Heatmap with differential pathway enrichment between progressors and nonprogressors. D, IFN-γ and IL16 pathways show more cell–cell interactions in progressors compared with nonprogressors. mem, memory; tox, toxic.

DOI: 10.1158/2326-6066.29456689

Authors: Parvathi Sudha, Travis S. Johnson, Habib Hamidi, Ke Yang, Enze Liu, Brent Smith, Vivek Chopra, Michael Nixon, Faiza Zafar, Sherif S. Farag, Gareth J. Morgan, Ola Landgren, Kelvin Lee, Attaya Suvannasankha, Magdalena Czader, Rafat Abonour, Mohammad Abu Zaid, Brian A. Walker

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4411967727

Cites:

Cited by:

Related to: 10