Investigation of the Biological Properties of Non‐small Cell Lung Cancer Using Three‐dimensional Computed Tomography Images
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background/Aim: We investigated the biological properties of non-small cell lung cancer (NSCLC) using three-dimensional computed tomography (3D-CT) images. Patients and Methods: We measured the diameters of surgically resected NSCLCs in the direction to the hilum and in the direction orthogonal to the hilum on the two largest cross-sections using 3D images, and classified NSCLCs into three types according to their shape. Correlations between each type and clinicopathological factors were determined. Results: We examined 369 cases: 129 Type A, 182 Type B, and 58 Type C. The tumor-shape types demonstrated significant correlations with histological type, tumor size, and pathological tumor size (pT), lymphatic invasion (Ly), and pleural invasion (pl) factors. There were significant correlations between Type A and adenocarcinoma (Ad), and between Type C and advanced T factor or larger size. The frequency of lymphatic invasion was increased in Type A but decreased in Type C, whereas pleural invasion was increased in Type C. Conclusion: NSCLC tumor shapes showed biological properties according to each histological type, such as pleural invasion or lymphatic invasion.
Source: Cancer Diagnosis & Prognosis
DOI: 10.21873/cdp.10458
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4411977622