Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND: rs2910164 on idiopathic male infertility. MATERIALS AND METHODS: In this case-control study, Blood samples were taken from 201 men with idiopathic infertility and 201 men in a healthy state for this case-control investigation. Genotype determination of desired polymorphisms was done using the Tetra-ARMS PCR technique and data was analyzed by SPSS software version 20. Significant associations were determined at an alpha level of 0.05. RESULTS: rs2858060 GG genotype and idiopathic male infertility in the recessive genetic model [odds ratio (OR)=2.02, 95% confidence interval (CI)=1.25-3.24, P=0.004]. After adjusting for age, body mass index (BMI), smoking, and alcohol consumption, the association between the genotypes and the disease remained significant. No significant association was observed between miR-146a rs2910164 genotypes and male infertility in all genetic models (P>0.05). Moreover, haplotype analysis showed that the CC (rs2858060/ rs2910164) haplotype is associated with the decreased risk of idiopathic male infertility (OR=0.728, 95% CI =0.54-0.98, P=0.035). CONCLUSION: rs2910164 in male infertility, further studies involving different ethnicity and larger sample sizes are needed to confirm our findings.
Source: PubMed
Authors: Zahra Sadat Hoseini, Leila Kohan
Institution: Islamic Azad University of Arsanjan
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4411977681