Year: 2025
Type: article
Abstract: Translational studies involving adoptive transfer of tolerogenic regulatory T (Treg) cells have been hindered by phenotypic instability of in vitro-induced Treg (iTreg) cells. Chen et al (Nature 2025 Mar 26; https://doi.org/10.1038/s41586-025-08795-5) conducted an unbiased genome-wide screen using clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology in primary human T cells to identify novel regulators of FOXP3 expression. Candidates were validated by integrating transcriptomic profiling and intracellular protein abundance at a single-cell level.
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,900
OpenAlex ID: W4411978191