Work

Case studies in neuroscience: movement-related cortical stimulation to enhance corticospinal transmission in chronic incomplete spinal cord injury

Year: 2025

Type: article

Abstract: We demonstrate that five consecutive days of movement-related cortical stimulation can enhance corticospinal excitability, expand motor maps, and improve volitional motor unit recruitment in a person with severe incomplete spinal cord injury. These results support the brain's adaptive capacity following spinal cord injury, despite limited motor drive to the muscle, and corroborate the potential to improve motor function by targeting higher-order networks during volitional motor intention with noninvasive brain stimulation.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00083.2025

Authors: David A. Cunningham, Christina V. Oleson, P. Hunter Peckham, Kevin L. Kilgore

Institutions: MetroHealth, Case Western Reserve University, VA Northeast Ohio Healthcare System

Language: English

Topic: Spinal Cord Injury Research

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Craig H. Neilsen Foundation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Center for Medical Rehabilitation Research