Year: 2025
Type: article
Abstract: To gain a more profound understanding of the nature of anxiety, this study utilized two animal behavioral models: the Open Field Test (OFT) and the Light/Dark Box Transition Test (LDT), using two groups of C57BL/6J mice: one with anxiety — like symptoms and the other without. In the LDT, the control group (healthy mice) showed a significantly higher tendency for active movement (P < 0.05) and a greater preference for exploring unfamiliar environments compared to the group of mice with anxiety, while the differences revealed by the OFT were less pronounced. Our findings highlight the effectiveness of these two animal models and the correlation between locomotive behavior and anxiety, which can be applied in future research.
Source: Studies in Psychological Science
Authors: Xiaonuan Wang, Yiru Zhang
Institutions: Beijing Normal University, Capital Normal University
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4411988904