Work

Multiomics Approach to Regionally Profile Zinc-Driven Host-Gut Microbiome Interactions in the Intestinal Tract

Year: 2026

Type: article

Abstract: Objectives: Zinc (Zn) is an essential micronutrient that regulates epithelial barrier integrity, immune signaling, and host–microbiome interactions in the gastrointestinal tract. Although Zn deficiency (ZnD) is associated with metabolic and inflammatory diseases with gut dysbiosis, how Zn availability shapes host–microbiome dynamics across intestinal regions remains unclear. Using integrative multi-omics, this work examines how dietary Zn status regulates regional Zn distribution, epithelial transcriptional programs, and gut microbial composition across the intestine and colon.

Source: Current Developments in Nutrition

DOI: 10.1016/j.cdnut.2026.109103

Authors: Savita C Sastry, Samuel Blake Mitchell, Abigail A Glick, Trista L Thorn, Alexander Lu, Tolunay B Aydemir

Institution: Cornell University

Language: English

Topic: Trace Elements in Health

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: gold

Estimated APC paid: $5,000