Work

Protective Potential of Kersen Leaf Ethanol Extract (Muntingia calabura L.) Against Hepatic Histopathology in Diabetes Mellitus Model Rats

Year: 2025

Type: article

Abstract: Kersen leaves (Muntingia calabura L.) are known as herbal plants used to lower blood glucose levels. This study evaluated the protective effect of ethanol extract of kersen leaves on the histopathology of the liver of white rats (Rattus norvegicus) model of diabetes mellitus. The experimental study with a Complete Randomized Design (RAL) involved five treatment groups and three replicates, using 55 streptozotocin (STZ)-induced mice. The results showed that the administration of 15% (K5) of kersen leaf ethanol extract improved the structure of hepatocytes, resembling normal tissue, compared to the positive control group (K2) who experienced severe necrosis and degeneration. In conclusion, 15% kersen leaf ethanol extract is effective in improving liver damage due to diabetes and potentially lowering blood glucose levels.

Source: Jurnal Penelitian Pendidikan IPA

DOI: 10.29303/jppipa.v11i5.10862

Authors: Nurlena Andalia, M. Ridhwan, Elvitriana, Armi, Jailani

Institutions: Universitas Serambi Mekkah, Universitas Syiah Kuala

Language: English

Topic: Natural Antidiabetic Agents Studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi, Direktorat Jenderal Pendidikan Tinggi