Work

Congenital Megalocornea, Microspherophakia, and Lens Subluxation Leading to Secondary Glaucoma in an Infant: A Case of Suspected LTBP2 Mutation

Year: 2025

Type: article

Abstract: We report the case of a 6-month-old infant with congenital megalocornea, microspherophakia, and bilateral lens subluxation, leading to secondary glaucoma. Genetic context included consanguinity, suggesting an LTBP2-related condition. The patient underwent bilateral lensectomy with anterior vitrectomy, combined with trabeculectomy and peripheral iridectomy in the right eye. Postoperative intraocular pressure normalized in both eyes. This rare entity should be distinguished from primary congenital glaucoma, as the surgical approach differs. Regular intraocular pressure monitoring is essential in children with megalocornea and lens anomalies to ensure early detection and treatment of secondary glaucoma.

Source: World Journal of Advanced Research and Reviews

DOI: 10.30574/wjarr.2025.27.1.2536

Authors: Ghizlane Daghouj, Sara Ennaki, Asmaa ElKettani, Zyad Laftimi, Loubna El Maaloum, Bouchra Allali

Institution: University of Hassan II Casablanca

Language: English

Topic: Ocular Disorders and Treatments

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4412035844