Year: 2025
Type: article
Study design: Observational Study
Abstract: Chimeric antigen receptor T-cells (CAR T cells) are genetically modified cellular immunotherapies approved as a standard of care treatment for patients with lymphoma and leukemia worldwide. Here, we report the initial activity in Brazilian centers through the collaboration between the Brazilian Cellular Therapy and Bone Marrow Transplant Society (SBTMO) and the Center for International Blood and Marrow Transplant Research (CIBMTR). A total of 104 patients who received commercial and academic CAR-T cells in Brazil between January 2020 and April 2025 were included. The median age was 56 years (range 4-83). Indications were Non-Hodgkin Lymphoma (NHL; 75 cases; 72%), Acute Lymphoblastic Leukemia (ALL; 23 cases; 22%), Multiple Myeloma (MM; 4 cases; 4%) and Chronic lymphoblastic leukemia (CLL; 2 cases; 2%). Anti-CD19 commercial CAR-T were 82% of the total, 68 for NHL and 17 for ALL). Most deaths were due to disease progression or relapse (n=19), followed by infections (n=8). The overall survival after a median follow-up of 200 days was 73% (95% CI: 62-86; N=63) for NHL and 79% (95% CI: 63-99; N=19) for ALL. This report demonstrates the successful initial implementation of CAR-T cells in Brazil among centers that report to the SBTMO/CIBMTR. This infrastructure will assist in further capturing the activity, assessing the outcomes, and complying with regulatory requirements.
Authors: Cinthya Corrêa da Silva, Anderson João Simione, Paula Moreira da Silva Sabaini, Antonio Vaz Macedo, Heliz Regina Alves das Neves, Monique Ammi, Flavia Ferreira da Costa, Celso Arrais Rodrigues, Adriana Mendes de Quadros Cavilha, Rosana Rocha Concilio, Phillip Scheinberg, Nelson Hamerschlak, Marco Aurelio Salvino, Adriana Seber, Yana Augusta Sarkis Novis, Vanderson Geraldo Rocha, Joaquim Gasparini, Lúcia Silla, Ricardo Chiattone, Andreza Alice Feitosa Ribeiro, Vaneuza Araújo Moreira Funke, Leonardo Javier Arcuri, Lucila Nassif Kerbauy, Jayr Schmidt Filho, Maria Claudia Rodrigues Moreira, Carmem Maria Sales Bonfim, Cilmara Cristina Kuwahara, Marcelo C. Pasquini, Fernando Barroso Duarte
Institutions: Hospital Israelita Albert Einstein, Hospital Amaral Carvalho, Hospital de Câncer de Barretos, Hospital de Clínicas Universidade Federal do Paraná, Universidade Federal do Paraná, Hospital Sírio-Libanês, Universidade Federal de São Paulo, Beneficência Portuguesa de São Paulo, Universidade Federal da Bahia, Support group for adolescents and children with cancer, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Hospital Nossa Senhora das Graças, AC Camargo Hospital, Complexo Hospitalar de Niterói, Medical College of Wisconsin, Hospital Universitário Walter Cantídio
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412035923