Year: 2025
Type: article
Study design: Case Report
Abstract: Paragangliomas are rare neuroendocrine tumours sharing embryological origins with phaeochromocytomas but differ in that they are found outside the adrenal medulla. The prevalence in literature ranges from 2 to 8 cases per million people. Pulmonary paragangliomas account for approximately 2% of this. Paragangliomas can cause symptoms due to the secretion of catecholamines. Other 'non-functional' paragangliomas may cause symptoms relating to mass effect or endobronchial obstruction. Once a diagnosis is made, the most common reported modality of management are lobectomy and endobronchial sleeve resection. Only a limited number of case reports describe other management modalities such as endobronchial ablation. We present the case of 48-year-old female with a right main bronchus endobronchial lesion identified on positron emission tomography (PET) dotatate scan on a background of succinic dehydrogenase B gene mutation (SDHB) familial paraganglioma. Bronchoscopic management with argon plasma coagulation (APC) probe ablation was used to debulk the lesion which resulted in excellent symptomatic improvement and stability on follow-up.
Source: Respirology Case Reports
DOI: 10.1002/rcr2.70265
Authors: Khuyen Hoang, Michael V. Brown, Arash Badiei, Phan Nguyen
Institutions: Royal Adelaide Hospital, The University of Adelaide
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,130
Funder: University of Adelaide
OpenAlex ID: W4412036465