Year: 2025
Type: article
Study design: Observational Study
Abstract: Introduction: Suboptimal clinical responses to metabolic and bariatric surgery include insufficient weight loss (WL), weight regain (WR), and/or comorbidity remission failure or relapse. Gut hormones' role in WR and Type 2 diabetes (T2D) relapse is not fully established. So, our aim was to evaluate the hormone profiles of patients with long-term optimal and suboptimal response after gastric bypass (RYGB). Methods: This cross-sectional study included 43 individuals who underwent RYGB surgery over 10 years ago, divided into two groups: 23 participants with no T2D history but different WR trajectories (cohort 1), and 20 with prior T2D diagnosis and optimal WL (cohort 2), with post-RYGB T2D remission (n=10) or relapse (n=10). Results: Fasting and postprandial glucose, insulin, C-peptide, glucagon, GLP-1 and GIP levels were evaluated during a mixed-meal tolerance test. In cohort 1, fasting glucose, insulin, C-peptide, and glucagon, as well as the postprandial glucose and GIP levels, were significantly positively correlated with %WR. Additionally, postprandial GLP-1 and glucagon levels were negatively correlated with the %WR. In cohort 2, higher postprandial glucose and lower insulin were observed in participants with T2D relapse. No other significant differences were observed. Discussion: In sum, greater WR was associated with higher levels of postprandial glucose and GIP, along with lower GLP-1 and glucagon excursions. Whether these are cause or consequence of WR remains to be clarified. Additionally, GIP and GLP-1 profile of participants with T2D relapse did not differ from those with T2D remission.
Source: Frontiers in Endocrinology
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funders: “la Caixa” Foundation, Danish Diabetes Academy, Sociedade Portuguesa De Diabetologia, Ministerio de Economía y Competitividad, Novo Nordisk, Novo Nordisk Fonden, Novo Nordisk Foundation Center for Basic Metabolic Research, Fundación Bancaria Caixa d'Estalvis i Pensions de Barcelona, Fundação para a Ciência e a Tecnologia
Awards: G2420745877, G2885439837, G3180925806, G3416057414, G342286053, G3660205263, G4230908485, G4504918650, Laboratório para a Investigação Integrativa e translacional em Saúde Populacional, G5132640529, Identificação dos sinais e mecanismos moleculares associados à falência terapêutica da cirurgia bariátrica, G5476537510, G553931797, G6077326861, Unidade Multidisciplinar de Investigação Biomédica - UMIB, G6997658380, G7685134749, G8221995800, G8351935874, Unidade Multidisciplinar de Investigação Biomédica - UMIB
OpenAlex ID: W4412038445