Work

Rerouting glucose metabolism of therapeutic T-cells for cancer: live longer, perform better

Year: 2025

Type: article

Abstract: A significant barrier to the success of adoptive cell therapies (ACTs) in cancer treatment is the inadequate persistence of T-cells following infusion. In vitro T-cell expansion is a crucial component of ACTs; therefore, preconditioning during culture may enhance their in vivo survival and therapeutic efficacy. Here, we discuss a recent article by Greg Delgoffe and colleagues that was published in Cell Metabolism in April 2025, providing evidence that pharmacologic metabolic rewiring of activated T-cells during in vitro expansion enhances their engraftment postinfusion and improves cellular immunotherapies.

Source: Immunometabolism

DOI: 10.1097/in9.0000000000000063

Authors: Zhongyi Dong, Jianmei W. Leavenworth

Institutions: University of Alabama at Birmingham, O'Neal Comprehensive Cancer Center

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Cancer Institute, National Institute of Allergy and Infectious Diseases