Association between creatinine-to-cystatin C ratio and handgrip strength in prediabetes patients: a nationwide cross-sectional study in China
Year: 2025
Type: article
Abstract: Background: This study aimed to investigate the relationship between the creatinine-to-cystatin C ratio (CCR) and handgrip strength in individuals with prediabetes, to identify patients with reduced handgrip strength. Methods: This study used a nationally representative sample from the Chinese middle-aged and elderly population. The cross-sectional portion utilized data from the first wave of the 2011 China Health and Retirement Longitudinal Study (CHARLS), while the longitudinal portion used data from the fourth wave of the 2015 CHARLS. Data on CCR, handgrip strength, and other relevant variables were collected and analyzed using univariate and multivariate regression. Results: A total of 2,704 participants were included, with 1,276 males (47.2%) and 1,428 females (52.8%), and the mean age was 60.5 ± 9.5 years. Univariate analysis showed a positive correlation between CCR and handgrip strength (β = 18.3; 95% confidence interval [CI], 16.46-20.14; p < 0.001). After adjusting for confounding variables, the β value was 3.52 (95% CI, 1.95-5.09; p < 0.001). Compared to the lowest CCR group (Q1, 0.27 to 0.67), the adjusted β values for Q2 (0.67 to 0.77), Q3 (0.77 to 0.89), and Q4 (0.89 to 2.39) were 0.37 (95% CI, -0.46 to 1.2; p = 0.38), 1.6 (95% CI, 0.73-2.47; p < 0.001), and 2.16 (95% CI, 1.24-3.09; p < 0.001), respectively. Subgroup and stratified analyses further supported these results. Conclusion: This study suggests that in individuals with prediabetes, there is a positive correlation between the CCR and handgrip strength.
Authors: Wenjing Zhang, Xianfang Huang, Kai Zhang
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412039954