Get started
Work

Association between dietary vitamin K intake and lipid metabolism among populations with cardiovascular disease

Year: 2025
Type: article
Abstract: Background: The objective of this investigation was to examine the correlation between intake of dietary vitamin K and lipid metabolism in cardiovascular disease populations. Methods: The data for this investigation were obtained from the National Health and Nutrition Examination Survey (NHANES) 2003-2014. The exposure variable was the total daily intake of dietary vitamin K (μg). Triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) comprised the lipid indicators. To investigate the relationship between vitamin K intake and lipid metabolism, the following analyses were conducted: weighted multiple linear regression, smoothing curve fitting, generalized additive models, threshold analysis, subgroup analysis, and sensitivity analyses. Results: Ultimately, 1,543 participants aged 18 years or older were enrolled. The total daily intake of dietary vitamin K was found to be negatively correlated with TG (β: -15.57, 95% CI: -27.806, -3.333) and TC (β: -6.564, 95% CI: -12.252, -0.877). For each 1 ug increase in the total daily intake of dietary vitamin K, the LDL-C would decrease by 0.510 mg/dl (95% CI: -0.940, -0.078) when the total daily intake of dietary vitamin K was less than 23.7 ug. HDL-C was not influenced by total daily intake of dietary vitamin K. Furthermore, subgroup analyses and sensitivity analyses revealed that an increase in the total daily intake of dietary vitamin K was still negatively associated with TG, TC, and LDL. Conclusion: The consumption of foods with high vitamin K levels might contribute to the improvement of TC, TG, and LDL-C levels in CVD populations.
DOI: 10.3389/fnut.2025.1605300
Language: English
Field: Nursing
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4412041696
FWCI: 0.551
Cites: 38
Cited by: 1
Related to: 10