Work

Electro-oxidative amination of benzylic C(sp³)–C(sp³) bonds in aromatic hydrocarbons

Year: 2025

Type: article

Abstract: ) bond to generate two carbocation fragments, which are subsequently captured by nucleophiles to form two C-N bonds. Mechanistic studies suggest that HFIP is critical as additive in adjusting the oxidation potentials of alkylbenzene substrates and amine products, effectively preventing overoxidation of products.

Source: Nature Communications

DOI: 10.1038/s41467-025-61017-4

Authors: Kai-Xuan Yang, Shu-Fan He, Qinhui Wan, Tianyi Xu, Daixi Li, Kexin Liu, Wenying Ai, Tao Shen

Institutions: Shanghai Jiao Tong University, Fujian Medical University, Xiamen University, Zhongshan Hospital of Xiamen University, Zhongyuan University of Technology

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $6,990

Funders: National Natural Science Foundation of China, Shanghai Jiao Tong University, Young Scientists Fund, Fundamental Research Funds for the Central Universities

Awards: G4474546436, G4871234068, G6481454678, G7441561454, G995971088

OpenAlex ID: W4412045830

FWCI: 2.086

Cites: 60

Cited by: 7

Related to: 10