Work

Periodontal and microbiological evaluation in cleft lip/palate patients undergoing orthodontic treatment: An in vitro study

Year: 2025

Type: article

Abstract: Periodontal and microbiological characteristic among cleft lip and/or palate patients undergoing fixed orthodontic treatment is of interest. Plaque and saliva samples showed high prevalence of Streptococcus mutans (83%), Lactobacillus spp. (67%), and Porphyromonas gingivalis (55%). In vitro analysis showed significantly greater biofilm formation on stainless steel brackets compared to ceramic brackets (p < 0.01), confirmed by SEM imaging. Elevated levels of IL-1β and MMP-8 in gingival crevicular fluid were positively correlated with microbial load (r = 0.72, p < 0.05). Thus, the influence of bracket material on biofilm formation and local inflammatory response is shown.

Source: Bioinformation

DOI: 10.6026/973206300211286

Authors: Sweta Yadav, Kalpana Yadav, Vibhuti Madhad, Ajay Kumar, Arpita Saha, Neha Agrawal

Institutions: Teerthanker Mahaveer University, University of Delhi, KIIT University, Index Medical College, Hospital & Research Centre

Language: English

Topic: Oral microbiology and periodontitis research

Subfield: Periodontics

Field: Dentistry

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4412048252