Effect of coenzyme Q10 on post-extraction tissue healing in wisdom tooth Surgery: double-blind randomized clinical trial
Year: 2025
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: AIM: This study primarily aimed to evaluate the efficacy of Coenzyme Q10 supplementation in improving post-extraction tissue healing and, secondarily, its effects on reducing temporomandibular disorders (TMD), dry socket and enhancing quality of life following wisdom tooth extraction. PATIENTS AND METHODS: This parallel randomized, double-blind, placebo-controlled trial included 70 participants, randomly assigned to receive either CoQ10 or placebo. The primary outcome was tissue healing, measured by clinical assessments on days 7, 14 and 30 post-surgeries; alongside secondary outcomes including the occurrence of TMD and dry socket occurrence. Additional secondary outcomes included physical and psychological recovery, assessed using the 36-item short form survey (SF36) and the 12-item general health questionnaire (GHQ12), which measure psychological distress and health-related quality of life. RESULTS: On day 7, the CoQ10 group showed a significant 45% improvement in tissue healing, compared to its counterpart and by day 14, showed a 55% improvement. TMD occurred in 12% of the CoQ10 group vs. 30% in the placebo group; and dry socket was 6% in the CoQ10 group vs. 18% in the placebo group. CONCLUSION: Coenzyme Q10 supplementation significantly accelerates tissue healing, reduces TMD and dry socket incidence and improves physical and mental health outcomes following wisdom tooth extraction. TRIAL REGISTRATION: ClinicalTrials.gov [registration number NCT06452134].
Source: Pain Management
Institution: Kurdistan University of Medical Sciences
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4412048710