Pemphigus vulgaris following radiotherapy in head and neck cancer: Clinicopathological perspective of a rare cutaneous manifestation after radiotherapy treatment
Year: 2025
Type: article
Study design: Case Report
Abstract: ABSTRACT: Pemphigus vulgaris triggered by the radiotherapy is rare and very few cases have been reported in the literature. Lesions within the radiotherapy field can be difficult to differentiate from post radiation dermatitis. Though exact pathogenesis is not understood, radiotherapy induced immunomodulation leading to bullous skin lesions, is thought to be critical. Here we present the clinicopathological perspective of pemphigus vulgaris involving the skin within and outside the radiotherapy portal, presented 2 weeks after the completion of radiotherapy. The condition requires multidisciplinary management and close coordination between oncologist, dermatologist, and dermatopathologist. Diagnosis is established based on the clinical presentation, histopathology, and direct immunofluorescence examination. Early institution of immunosuppressive therapy can improve the skin lesions and reduce the morbidity significantly.
Institution: All India Institute of Medical Sciences Bhopal
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412049212