Analysis of clinicopathological factors associated with recurrence after post operative radiotherapy in oral cavity squamous cell carcinoma
Year: 2025
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Surgery is the primary course of treatment for most patients with oral cavity tumors; however, adjuvant radiation is advised to increase the likelihood of locoregional cancer control in the presence of adverse risk factors such as pathological tumor (T3/T4) stage, nodal metastases, perineural invasion, lymphovascular invasion, and positive margins. In the present study, the outcome was assessed after post-operative radiotherapy along with factors associated with recurrence in patients with oral cavity squamous cell carcinoma. MATERIAL AND METHODS: This retrospective study included postoperative oral cavity squamous cell carcinoma (OCSCC) patients treated with adjuvant radiotherapy. Patient characteristics, factors associated with failure, and overall survival were analyzed. RESULTS: 196 patients of OCSCC were analyzed. Age <40 years, tumors (>4 cm), presence of bone invasion, Depth of invasion >10 mm, positive or close surgical, extranodal extension positive had a higher risk of recurrence in oral cavity cancer. Also, a significant association was seen between pathological nodal stage (P < 0.001). The median overall survival was 20.2 months (13.8-32.9). There was a statistically significant association between stage, concurrent chemotherapy, and overall survival (P < 0.05). CONCLUSION: The present study identified that advanced stages, >10 mm depth of invasion, presence of perineural invasion, the worst pattern of invasion of 5, bone invasion, younger age, and node-positive OCSCC were poor prognostic factors. In early-stage oral cavity cancers, the decision to administer postoperative radiation should be judged by pathological adverse risk factors.
Authors: Jyoti Singh, Sweety Gupta, Sanjay Sajeevan, Debanjan Sikdar, Abhishek Chakravarty, Sumit Singh, Deepa Joseph, Manoj Gupta
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4412049256