Work

Chemoresistance: The hidden barrier in cancer treatment

Year: 2025

Type: article

Abstract: Despite significant advances in cancer diagnosis and therapy, the global burden of cancer continues to escalate, characterized by increasing incidence and mortality rates. A problem for successful treatment is chemoresistance, which undermines the effectiveness of traditional and targeted treatments. This review synthesizes emerging therapeutic strategies, including targeted agents, combinatorial regimens, and advances in precision medicine, with a focus on improving clinical outcomes. Integrating the latest understanding from molecular biology, genomics, and pharmacology emphasizes new paths to overcoming resistance. Particular attention is focused on the roles played by exosomes, metabolic reprogramming, and the tumour microenvironment in facilitating drug resistance, as well as promising approaches to counteract these mechanisms and improve therapeutic responsiveness.

Source: Cancer Pathogenesis and Therapy

DOI: 10.1016/j.cpt.2025.07.001

Authors: Vivek Kumar Dhiman, Manju Kumari, Devendra Singh

Institutions: Chettinad Academy of Research and Education, King George's Medical University, Shri Ramswaroop Memorial University

Language: English

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,100