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High occurrence of antiphospholipid antibody-associated thromboembolism in systemic lupus erythematosus with significant pulmonary hypertension: A monocentric retrospective study in southern taiwan

Year: 2025

Type: article

Abstract: OBJECTIVE: Pulmonary hypertension (PH) has an increased risk of death, and affects systemic lupus erythematosus (SLE) with different classification and variable severity, requiring the individually therapeutic approach. Larger-scale monocentric retrospective studies analyzing the prevalence, classification and therapeutic modalities of PH in SLE can provide important local experience to improve management. METHODS: A retrospective study was performed in 1595 hospitalized SLE patients in southern Taiwan from January 1, 1990 to December 31, 2024. Symptomatic patients with significant PH, pulmonary artery systolic pressure over 45 mmHg by transthoracic echocardiographic examination, were analyzed for the prevalence, classification and therapeutic modalities, focusing on the presence of antiphospholipid antibody (aPL)-associated thromboembolism (TE). RESULTS: 198 patients (12 %) had aPL-associated TE. Significant PH was identified in 106 patients (7 %), classifying into left heart disease (LHD) in 64 %, pulmonary artery hypertension (PAH) in 23 %, and pulmonary artery obstruction (PAO) in 13 %, including chronic thromboembolic PH (CTEPH) in 12 %. Among patients with significant PH, 55 (52 %) had aPL-associated TE and were treated with secondary prophylaxis, including anticoagulants and antiplatelets. In addition to surgical interventions, cardiac supportive agents and PH-targeted drugs were prescribed for patients with LHD and CTEPH/PAH, respectively. By multivariable logistic regression analysis, pulmonary infarction was identified as a risk factor for the development of CTEPH after acute pulmonary embolism in SLE. CONCLUSION: In this larger-scale monocentric retrospective study from southern Taiwan, significant PH was identified in 7 % of hospitalized SLE patients and 52 % of such cases had aPL-associated TE, requiring the secondary prophylaxis with anticoagulants and antiplatelets.

Source: Journal of the Formosan Medical Association

DOI: 10.1016/j.jfma.2025.06.039