Preparation and Characterization of Magnesium Implants with Functionalized Surface with Enhanced Biological Activity Obtained via PEO Process
Year: 2025
Type: article
Abstract: This study presents the development and comprehensive evaluation of magnesium-based implants with surface modifications using selected polymers and bioactive compounds. The implants were fabricated via plasma electrolytic oxidation (PEO), followed by the application of chitosan, polydopamine (PDA), and gold nanoparticles as bioactive surface coatings. In vitro experiments, including FT-IR spectroscopy, scanning electron microscopy (SEM), wettability tests, biodegradation assays in simulated body fluid (SBF), electrochemical corrosion analysis, and cytotoxicity tests using MG-63 osteoblast-like cells, were employed to assess the physicochemical and biological properties of the materials. The PEO + PDA-modified samples demonstrated the highest corrosion resistance (−1.15 V corrosion potential), enhanced cell viability (~95%), and favorable surface wettability (contact angle ~12.5°), outperforming other tested configurations. These findings suggest that PEO combined with PDA offers a synergistic effect, leading to superior biocompatibility and degradation control compared to unmodified magnesium or single-coating strategies. The developed implants hold promise for orthopedic applications requiring biodegradable, bioactive, and cytocompatible materials.
Source: Processes
DOI: 10.3390/pr13072144
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,896
OpenAlex ID: W4412068290