Work

Angiomatosis of soft tissue

Year: 2025

Type: article

Abstract: Angiomatosis of soft tissue (AST) is a rare, benign vascular anomaly primarily characterized by extensive mesenchymal hyperplasia with a predilection for the lower extremities. It often presents in early life, complicating the diagnosis because of overlapping clinical and radiological features with other vascular malformations. The etiology of AST remains largely unknown, although somatic mutations, particularly in the PIK3CA gene, have been identified. Clinically, patients typically exhibit persistent swelling and pain, with imaging modalities revealing infiltrative soft tissue masses. Diagnosis is frequently confirmed postoperatively as specific criteria remain absent. Differential diagnoses include conditions such as venous malformations and fibro-adipose vascular anomalies. Current treatment mainly involves surgical excision; however, the high recurrence rates necessitate further exploration of targeted therapies. This review aimed to systematically discuss the current understanding of AST, emphasizing the need for improved diagnostic and management strategies.

Source: Chinese Journal of Plastic and Reconstructive Surgery

DOI: 10.1016/j.cjprs.2025.06.006

Authors: Jiayi Lai, Li Hu, Xiaoxi Lin

Institutions: Shanghai Jiao Tong University, Shanghai Ninth People's Hospital

Language: English

Topic: Vascular Malformations and Hemangiomas

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $980