Work

Nano carbon dot-collagen peptide – Hydroxyapatite composite coating for bone tissue regeneration

Year: 2025

Type: article

Abstract: Biological derivatives are the preferred coating materials for enhancing osseointegration in bone implants. The present study aimed to develop a nanocomposite from fish waste, comprising of carbon dots (CD), collagen peptides (CP), and natural hydroxyapatite (HAP), to serve as a coating material for titanium implants, so as to facilitate rapid tissue regeneration. The nanocomposite (CD-CP-HAP) was synthesized using a two-step protocol. Fourier Transform Infrared (FTIR) and UV-Visible spectroscopic studies confirmed the interaction between carbon dots (CD) and collagen peptides (CP) through conjugated C C and OH---NH hydrogen bonding. Additionally, the phosphate (PO₄³⁻) group of hydroxyapatite (HAP) interacted with the NH and OH functional groups of CD and CP, as evidenced by the presence of OH absorption in multiple environments. The titanium strips coated with the nanocomposite demonstrated a significant increase in polarization resistance, highlighting their potential for bone regeneration applications. The cell toxicity assay indicated that the composite is biocompatible, and has the potential to be used as a coating material for bone implants to enhance bone tissue regeneration.

Source: Next Materials

DOI: 10.1016/j.nxmate.2025.100914

Authors: P.Muhamed Ashraf, K.R. Vrindha, P.K. Binsi, Nebu George Thomas

Institution: Central Institute of Fisheries Technology

Language: English

Topic: Bone Tissue Engineering Materials

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,280